Mitochondrial Stress Evokes Reduced Activity of the Ubiquitin/Proteasome-System Modulating Pathogenesis of Human Metabolic Diseases
نویسندگان
چکیده
Segref, A., Kevei, É., Pokrzywa, W., Schmeisser, K., Mansfeld, J., LivnatLevanon, N., Ensenauer, R., Glickman, M. H., Ristow, M. and Hoppe, T. (2014) Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system. Cell Metabolism, 19 (4). pp. 642 652. ISSN 15504131 doi: https://doi.org/10.1016/j.cmet.2014.01.016 Available at http://centaur.reading.ac.uk/65857/
منابع مشابه
Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system.
Mitochondria maintain cellular homeostasis by coordinating ATP synthesis with metabolic activity, redox signaling, and apoptosis. Excessive levels of mitochondria-derived reactive oxygen species (ROS) promote mitochondrial dysfunction, triggering numerous metabolic disorders. However, the molecular basis for the harmful effects of excessive ROS formation is largely unknown. Here, we identify a ...
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